Yes. When I first started, it really messed with me. I would get super sleepy and tired and would start falling asleep on my feet. Then I switched to taking it in the evening and that was okay until the dose was increased...Then I started having stomach issues (the runs ...yikes)...SO then we played around with the dose. It was lowered significantly and then I was put on Welbutrin in additon to the Zoloft and tha made things worse...Got off the Wellbutrin fairly quickly and back to ZOloft and I had to adjust again to each increase in dose. Seem I am finally used to it now. It all too several months for me. Hang in there...Although, I see your posts are form a few months ago. I hope things are better now?