What side effects are associated with Prestiq withdrawl? On the lowest dosage, should one still taper off? My blood pressure went up and my PCP advised I stop taking it. My blood pressure is usually very low, so even though it wasnt super high, the increase was big. I went down to taking it every other day for s week. Then I had an appointment with the pdoc. He said the bp wasnt THAT high. I told him my chest hurt and he said to just stop taking it for a month. During the past two weeks, I have been very irritable and unusually confrontational. I am typically a very patient person. I have also been exhausted. I think the irritability may be decreasing now, but Im not sure if I want to go back on the prestiq, even if my BP doesn't return to normal.