Really? None of them (SSRIs or SSNIs) work for me. I've been on all of the SSRIs and most of the SSNIs. Enough to say it doesn't work for me. And though I have PTSD and not Major Depressive Disorder, i still have major depression and major anxiety.
Like you are saying, MDD and being majorly depressed as a PTSD symptom are different things. It’s not necessarily surprising that they don’t respond to the drugs the same way. You also have BPD, which likely influences some stuff too, I’d imagine suicidality being quite affected by that.
I appreciated the genetic test. It didn’t help me find a working drug, but it did shed light on why I seem to need higher doses and why many psych meds I’ve tried havent worked long-term. Even if the science is still baby-science, it’s still something to work with. And that provides a little bit of logic in what can feel like an overwhelmingly random illness. Which, then, provides a toehold for a cognitive shift....which also helps.
@anthony has said before, and I very much agree - the placebo effect is incredibly relevant to mental health treatment, and should not be underestimated. A person must address the cognitive side of things, in conjunction with any kind of treatment protocol: meds, or therapy, or supplements...anything.
The way we think about things determines (to a large extent)
how we think And how we think correlates directly to how we feel, and what we do.
A piece of the puzzle. Not all, but vital part.