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A thread for scientific nerdiness

I have learned that a lack of micro-nutrients and an imbalance of electrolytes can impair cognitive function and elevate mood changes, shifting electrolyte levels can cause Brain Fog. Those who suffer high blood glucose levels are at risk of blood stasis and poor blood circulation to the micro-capillaries. This is bad for the kidneys when they do not balance the sodium, potassium, phosphates, water, and electrolytes in the bloodstream. I'm not sure to what extent that this has an effect on people with PTSD, or any other disorders people have, but different levels of bio-electric energy levels in the brain can produce a most undesirable effect on the bio-rhythm of peoples emotions. I'm not sure if ''Benzodiazepines'' do what they claim, being that how can you target and isolate just one part of the brain and treat it without doing harm or adverse effect on the rest of the brain. my question is....do Benzodiazepines know exactly where to go, and where not to go? It would be my thought that what if Benzo's Create a Neurological Wave that Triggers the Sensors of Aggression and Switches Off Inhibitors. I am not a chemist or a physicist to report any theory and stand behind it. I have Autism and for all I know I could have been born with the predisposition to have PTSD as well, I don't know, I was not evaluated.
 
looking to the wrong part of

I wouldn't compartmentalize the disorder so much when considering the neurobiology. It is useful for discovering details in one system but eventually you must piece them all together. The hypothalamus has been researched in PTSD quite a lot. It is vital to the catecholamine disruption in PTSD. I think the locus coeruleus is also important in that regard.

The problem with understanding the brain's involvement in PTSD is that it's only part of the battle. Say it is the hypothalamus and cortisol is involved. How do we fix that?

steroids? exercise? talk therapy? diet?

Some people have died and suffered brain damage in clinical trials for some medications that have effects on the glucocorticoid receptors, it can cause cytotoxicity. Determining the effectiveness of therapy and lifestyle choices is difficult as well. Then there's economics and politics to complicate access to treatments.

Some changes persist. You can not unbake a cake. Chemical changes are tricky to reverse. Some parts of the brain are like cake. Squishy and irreversibly burnt ?

Benzodiazepines know exactly where to go, and where not to go? It would be my thought that what if Benzo's Create a Neurological Wave that Triggers the Sensors of Aggression and Switches Off Inhibitors

It depends on the benzodiazepine. Most are pretty selective for gaba inhibitors if i'm not mistaken? Even if they effect only one receptor, that one receptor is connected to ALL the body and effects it all.

When they wear off and leave your body there will be a rebound effect. This can cause excitation and aggression.

You can also have disinhibition from amnesia caused by their use, overdose and intoxication can cause it, and contradictory reactions in some people make them aggressive or feel panic.

They are supposed to be used for crisis stabilization and most often than not they sedate you. If you are aggressive while using benzos you probably took too much, are not metabolizing them well and therefore took too much, or you are withdrawing or addicted to them. Messing with GABA too much will make a person very unstable and possibly even kill them from seizures and dysregulation of homeostasis.

Short answer, yes they can inhibit certain stuff and cause aggression. You shouldn't use them unless its an emergency that requires medical sedation
 
I wouldn't compartmentalize the disorder so much when considering the neurobiology. It is useful for discovering details in one system but eventually you must piece them all together. The hypothalamus has been researched in PTSD quite a lot. It is vital to the catecholamine disruption in PTSD. I think the locus coeruleus is also important in that regard.

The problem with understanding the brain's involvement in PTSD is that it's only part of the battle. Say it is the hypothalamus and cortisol is involved. How do we fix that?

steroids? exercise? talk therapy? diet?

Some people have died and suffered brain damage in clinical trials for some medications that have effects on the glucocorticoid receptors, it can cause cytotoxicity. Determining the effectiveness of therapy and lifestyle choices is difficult as well. Then there's economics and politics to complicate access to treatments.

Some changes persist. You can not unbake a cake. Chemical changes are tricky to reverse. Some parts of the brain are like cake. Squishy and irreversibly burnt ?



It depends on the benzodiazepine. Most are pretty selective for gaba inhibitors if i'm not mistaken? Even if they effect only one receptor, that one receptor is connected to ALL the body and effects it all.

When they wear off and leave your body there will be a rebound effect. This can cause excitation and aggression.

You can also have disinhibition from amnesia caused by their use, overdose and intoxication can cause it, and contradictory reactions in some people make them aggressive or feel panic.

They are supposed to be used for crisis stabilization and most often than not they sedate you. If you are aggressive while using benzos you probably took too much, are not metabolizing them well and therefore took too much, or you are withdrawing or addicted to them. Messing with GABA too much will make a person very unstable and possibly even kill them from seizures and dysregulation of homeostasis.
I wouldn't compartmentalize the disorder so much when considering the neurobiology. It is useful for discovering details in one system but eventually you must piece them all together. The hypothalamus has been researched in PTSD quite a lot. It is vital to the catecholamine disruption in PTSD. I think the locus coeruleus is also important in that regard.

The problem with understanding the brain's involvement in PTSD is that it's only part of the battle. Say it is the hypothalamus and cortisol is involved. How do we fix that?

steroids? exercise? talk therapy? diet?

Some people have died and suffered brain damage in clinical trials for some medications that have effects on the glucocorticoid receptors, it can cause cytotoxicity. Determining the effectiveness of therapy and lifestyle choices is difficult as well. Then there's economics and politics to complicate access to treatments.

Some changes persist. You can not unbake a cake. Chemical changes are tricky to reverse. Some parts of the brain are like cake. Squishy and irreversibly burnt ?



It depends on the benzodiazepine. Most are pretty selective for gaba inhibitors if i'm not mistaken? Even if they effect only one receptor, that one receptor is connected to ALL the body and effects it all.

When they wear off and leave your body there will be a rebound effect. This can cause excitation and aggression.

You can also have disinhibition from amnesia caused by their use, overdose and intoxication can cause it, and contradictory reactions in some people make them aggressive or feel panic.

They are supposed to be used for crisis stabilization and most often than not they sedate you. If you are aggressive while using benzos you probably took too much, are not metabolizing them well and therefore took too much, or you are withdrawing or addicted to them. Messing with GABA too much will make a person very unstable and possibly even kill them from seizures and dysregulation of homeostasis.

Short answer, yes they can inhibit certain stuff and cause aggression. You shouldn't use them unless its an emergency that requires medical sedation
 
My wife has been diagnosed and her Dr. has been prescribing them to her for quite some time and now they (DEA) has a new trick up their sleeve to save people from doing wrongful harm to themselves by eliminating diazepines if you use opioids to manage chronic pain. She's all bent out of shape but I think this will help her in the long run, even though she doesn't see it now. I've been looking into Traditional Chinese Medicine and herbal remedies that may help to change her way of thinking that all is lost...like I can see the forest through the trees, even though she can't at the moment. I'm a bit cynical when it comes to Western medicine (Big Pharma) cause they get paid more to do less !!! Yea she has kidney failure and had it long enough to do harm and it took till now to find out from her primary care, that's like putting a speed bump sign after you drove over the bump. I'm seeing a pattern of diabetes, CKD, and heart failure, and not much is being done to address this issue. I'm wondering if PTSD can be stabilized with TCM and meditation, and an overall healthy diet, especially brain food.
 
my question is....do Benzodiazepines know exactly where to go, and where not to go?
Where "knowledge" pertains to a defined molecular structure that can only interact with specific complementary receptors, as opposed to cognizance; yep ;)
 
because evolution may be a theory, but so is gravity. and it's a f*cking awesome one at that.
also a friendly PSA to only take antibiotics as directed, and limit the consumption of antibiotic-treated animals if you're omnivorously inclined :tup:
 
We don't have free will in my opinion. I was first exposed to this idea through the church and interestingly, the Maharaj says the same thing. He uses different words. The concept is predestination or free will. Do we choose God or dose He choose us in the church. Outside the church it's just do we have free will or not. I say no.

That's the philosophical side.

The science part is the physics and that this explanation, that we have no free will which is known as superdeterminism (or that's one term for it) has been put forward as a solution to solve for and produce the theory of everything.
(Solve for spooky action at a distance)

It's wildly unpopular however.

But it's soothing to me. People are so adamant that they have free will or that we are responsible for the mess most of us are in, IDK why, but if you want people to start yelling, hit them with the idea.

There is a scientific basis for what I'm saying and I'll give my sources in another post. I've found a naughty girl theorehitical physicist on YouTube recently. (Love YouTube) She says the same thing, and so did Herr Einstein pretty much, not that it's a solution but a possible one, but again, no one likes it.

I'm not a scientist theologian or scholar but I'm a curious person and I used to like to read a lot. Being able to grasp the fundamental ideas behind what the scientists are working on is fun and interesting.
 
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The comments on that one were better than the article imo.
Agreed.

--
Deterministic theories put forth the idea that there is no free will.
But.
At the level that this is currently debated, I don't think it is appropriate, nor beneficial, to incorporate in the literal sense into society.
In fact, I feel that its incorporation into society at this stage, would lead to a total breakdown.

Murders... thefts... assaults... etc. But no consequences relevant anymore because "but Officer, it isn't my fault as I've no free will."

Condense and develop the theory at a physical level, and then and only then consider it at the societal.
 
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Agreed.


Deterministic theories put forth the idea that there is no free will.
But.
At the level that this is currently debated, I don't think it is appropriate, nor beneficial, to incorporate in the literal sense into society.
In fact, I feel that its incorporation into society at this stage, would lead to a total breakdown.

Murders... thefts... assaults... etc. But no consequences relevant anymore because "but Officer, it isn't my fault as I've no free will."

Condense and develop the theory at a physical level, and then and only then consider it at the societal.
That's the argument but I think it's wrong. The breakdown would come from the idea there are no consequences.

Whenever I would try and propose the idea to my wife she'd say "why not just kill someone?"
Which of course means you think there are no consequences for your decisions.

Like the article said however this is not sound and reality teaches everyone but sociopaths there are consequences for your decisions and you're responsible, free will or not.

Your opinion is shared by most and the idea there can't be free will frowned upon.
 
Deterministic theories put forth the idea that there is no free will.
But.

:hilarious: yeah, I was more at, social science concepts best not judged by other science criteria, but there could be so many objections to the whole line of thought.... just from the methodology implications of it for other life.

I think their free will is not even non existent... but worse, ill defined.
 

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