My dr upped my seroquel to 600mg before I go to bed. I thought seroquel makes you tired but it takes 2 hrs before I am ready to sleep. Is that common? My dr said he might have to give me a higher dose. I take it for sleep and moods. He just told me I am bipolar also with the ptsd. i also take 300mg of effexor in the morning. I am just a little worried about taking so much seroquel. I have taken just about every antidepressant there is and none if them helped that is why he put me on seroquel.