Recently I was put on 450. It's s lot and I'm fairly small. I believe I was manic the first week with moments of uncontrollable crying and weird emotions, both good and bad. It evened out after that and has helped me greatly with daily motivation. Side effects for me are: insomnia, racing heart, heart palps, anxiety, weight loss, no appetite, and intolerance to high heat (like hot yoga , which I love!).
I'm not a doctor,
@Nam, but I've been on varying strengths of wellbutrin. 450 is definitely a lot - there's no evidence of improved results over 400. Your size won't affect how it hits you, it's more to do with metabolizing rates of the drug into the brain. But since you are having all the classic side effects of a too-high dose, I'd encourage you to talk with your doc about backing down.
Also, with Wellbutrin, there is a difference between the generic and the name-brand. It's a shame, but you have to be careful. The generics made by Actavis, Mylan, and Par Pharmaceutical have been re-tested for equivalency in strength and in 2012 the FDA said they passed testing (reference
here), but what I can find from 2013 says that only Mylan and Par Pharmaceutical are fully tested and approved (reference
Dead Link Removed).
I know that I experienced a marked difference on generic buproprion manufactured by Impax, and that was when I went looking and discovered that it was made by a parent company that the FDA had asked to recall their buproprion. The recall was announced late 2012. I got this recalled generic from my pharmacist in early 2014. So, it's worth checking.
Also, after some tweaking, I discovered that I respond better to taking two 200mg SR (short release) per day than one 400mg Xl (extended release). So, that's worth looking into as well.
@theotherside, definitely nausea for me when I started it. I also had a side effect known as 'false euphoria' - after about 2 weeks everything got really, really better. It was amazing how much better I felt. And that went away about 2 weeks later. The drug does seem to work for me, it just has never produced that one-time potent effect again. But it's part of what keeps me functional.