I have 2 sisters that are twins and are 11 yrs older than me. One I cut all ties with, the other, I have limited contact with, and no contact with her 2 adult daughters who are very toxic. Was a good choice. I have a daughter that is 44 that is unmedicated bi polar, a drug addict, a crisis addict, etc. I have not cut ties with her but have set strong boundaries now. She is so toxic and draining. She constantly makes bad choices with men and with parenting her kids. She goes MIA frequently. I stopped having her and her family for holidays in 2019. I could not take the drama any more. Life is calmer now.