Mehta says it’s impossible to say whether it was simply the early timing of the child abuse or something unique to being mistreated by caregivers that accounted for the different pattern of changes she and her colleagues found.
Nail. Head.
“The important thing about this paper is that it looks at PTSD that has different life histories. One group has a life history of child abuse and the other doesn’t and we see a completely different functional genomic appearance.”
I feel like I want to take this paper and wave it in front of my GP's face. I have in the past detected a tone on some threads on the forum tha have been angrily dismissive of the fact tha some users weren't hurrying up and recovering. Or that they were dilly dally and hanging onto thepray like a security blanket. Well, I suppose this is the end of the road in a way. I mean I pretty close to having dug out most of the compacted emotional residue that has battered me around over the years. I've definitely blown a few fuses and I don't think I'll get hat functionality back. But I'm not going to flog myself to death trying, or spend my life in some guilt ridden approach because I 'should be getting back to normal'.
“This study implies that it is essential to take into account the trauma history of an individual,” says Mehta, “Individuals with the same diagnosis might need different treatments depending on their environmental endowments together with their genetic predispositions.”
I think I'm owed a big ass apology, by many many people, for putting me down and making me feel like ****.
Also I can' help thinking that seen as more girls get abused than boys, well sexually abused anyway, which is the most biologically invasive, especially for girls....then perhaps some wider medical ethos needs to change. I need to think on this some more, its rather impactful.
some studies found that a childhood history of maltreatment was associated with a reduced response to antidepressants and some other therapies.
NO S**T SHERLOCK!! I've only been saying since 1999, I'm not depressed, I'm traumatized. 'I don' wan your anti-depressanst, I'm not depressed.....over and over and over and over, until you start to question your own sanity.
“The question is, if indeed the problem is in the DNA, can we reverse this program and do we have tools to reverse that?” says Szyf. “I’m very interested in that and we’re doing some experiments in animal models.” The group is using drugs that can affect gene expression, such as some cancer treatments, for example, to figure out whether they can help to reverse harmful epigenetic changes like those leading to PSTD-like symptoms in animals.
Depending on the patient’s experience, for example, trauma linked to childhood abuse may respond better to certain drugs acting on one pathway, while adult-onset trauma, such as being a victim of rape, might require targeting a different set of genes or proteins. The more we understand how trauma does harm, the better able we will be to reverse the damage or even actually prevent it from causing disease.
How do others feel about this? I feel guarded/resistant. I feel that some things can't and shouldn't be remedied by drugs. I'm human not a pesserie dish experiment and do others not find it peverse that a neuroscientist/physcologist can make the connection about lack of good attachment and think a pill can replace that? I mean, obviously if some sufferers have contracted debilitating conditions as a result then I can see why a drug would be useful to tackle that specifically and alleviate the extra hardship the sufferers body has to fight but..if no such disease is present then I'm not sure I would want pills to fix me...I've gone through enough dodgy and complicated sates of consciousness thank you. What would make me feel better was greater public understanding, empathy from the medical sector, just plain old understanding and to be cut some slack by my gp when I'm struggling. I suppose what I'm saying that even if a pill cane mimic or replicate the love and trust lost over a childhood and subsequent life time, it's a pill, it's not a person. Why do the medical profession not get that. Having medical professionals simply admit that would be worth it's weight in gold to a persons physical and mental health and self perception.