[DLMURL="https://www.ptsdforum.org/c/members/scaredoflonely.1860/"]ScaredOfLonely[/DLMURL]
i am not tring to attacking you ...
for real , i was thinking you are joiking because you said that you
"need" to tell them the 100% true about all their excluding questions . but forget it. lets talk about the drug .
"Preclinical and clinical evidence suggests that low levels of the neurosteroid allopregnanolone (ALLO), a metabolite of progesterone, contribute to the pathophysiology of PTSD. ALLO is a potent modulator of brain gamma-amino-butyric acid (GABA) inhibitory receptors and has anxiety-reducing, sedative, anticonvulsant, and neuroprotective effects. ALLO levels have been related to PTSD or PTSD-like symptom severity and treatment response in human and animal studies. Direct replacement of ALLO would thus seem to be a promising and novel way to treat PTSD. However, ALLO is not orally bioavailable, and produces active steroid metabolites that are potentially of concern for long term treatment.
Ganaxolone is a modified, synthetic version of ALLO with similar pharmacological and behavioral effects, good bioavailability, and no signal for tolerance. Therefore, ganaxolone is among the first commercially viable neurosteroid treatments and is furthest along in development as a potential FDA-approved medication. Ganaxolone has been studied so far in epilepsy and has demonstrated good tolerability and safety in >900 subjects
"
I know for sure that my
gaba is fu**ed because when i got ptsd, it with nomber of symptoms very simmilar to the
Benzodiazepine withdrawal syndrome -
"is the cluster of
symptoms that appear when a person who has taken
benzodiazepines long term and has developed
benzodiazepine dependence stops taking benzodiazepine drug(s) or during dosage reductions
"
the reason for those symtomps is (wiki)
-
" Benzodiazepines potentiate the action of the neurotransmitter GABA. When this potentiation is sustained by long-term use, neuroadaptations occur which result in decreased GABA activity and increased excitability of the glutamate system. When benzodiazepines are stopped, these neuroadaptations are "unmasked" leading to excitability of the nervous system and the appearance of withdrawal symptoms
"
So , I am very curious to tru it and i hope it will be approved for PTSD or
at least for epilepsy....
