DharmaGirl
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It worked for a few weeks then they had to up the dose so much I was passing out from low blood pressure.
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Study Has The Prazosin Study Been Mentioned Yet?
- Post starter EloiseLandau
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I currently take this before going to bed. It has cut down on nightmares and when I do have one, it isn't with the intense feelings and anxiety they used to leave behind. I can also wake up (which I do several times a night anyway) but roll over and go right back to sleep without waking up in the AM feeling like I woke up severral times during the night. IMHO it is best to take it at night at least to start but listen to your doctor.
I can't wait to try this med now. I can't remember ever sleeping through the night and everytime I wake up it takes a bit to get back to sleep.
I am just waiting for the Dr from the tele phyc to send the prescription to my family dr.
I found this and thought it was interesting. Not sure if this has been posted.
HPA dysfunction in the form of hypoactive HPA axis or hypocortisolism -
Two similar studies by M. Kabbaj et al showed that chronic treatment with alpha 1 antagonist prazosin reduced hippocampal corticosteroid receptors and increased cort. response to stress. In particular, high responder rats did were not affected, but low responder rats, which had increased brain MR/GR and more efficient negative feedback, were affected (decreased cort. receptors and increased cort. response). In the other study, rats adrenalectomized and sub. with cort. who were treated with praz. chronically, showed a reduction in hippocampal MR levels, while adrenal-intact rats showed a reduction in hippocampal GR, and enhanced cort. responses following stress.
Another study was done where chronic treatment with prazosin to early abstinent alcoholics for 5 weeks seemed to reverse the blunted HPA response to stressors.
After 5 weeks with the alpha 1 antagonist, the praz. group was tested with stressors and showed a robust cort. response, in comparison to the placebo group which showed blunted response. It is said that HPA dysfunction in early abstience is marked by blunted HPA responses to stress and this increases relapse risk. The author of the study attributed the cort. response to higher NA levels as a response to blockade, but did not consider the possibility that maybe praz. was somehow affecting CRh or hippocampal corticosteroid receptors involved in the feedback system. The two groups showed identical cort levels prior to stress test, and only the praz. group produced healthy cort responses to the stressors.
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Many veterans with PTSD use this drug and find it to be helpful for aspects of their condition, mainly helping to sleep and have less nightmares.
What does chronic blockade of alpha-1 adrenergic receptors do to the HPA axis? Could it be helpful in the hypoactive HPA observed in many cases, such as CFS, PTSD where enhanced negative feedback is one of the key features.
I spoke with one of the researchers of the two studies done on the rats, and they said that this drug does show promise in HPA dysfunction, but there is no money for more studies, or studies on humans. this is an old drug, and its already being used in PTSD simply because NA drive is observed to be hyperactive in PTSD.
[DLMURL]http://pubget.com/paper/17552999/Individual_differences_in_the_effects_of_chronic_prazosin_hydrochloride_treatment_on_hippocampal_mineralocorticoid_and_glucocorticoid_receptors[/DLMURL]
HPA dysfunction in the form of hypoactive HPA axis or hypocortisolism -
Two similar studies by M. Kabbaj et al showed that chronic treatment with alpha 1 antagonist prazosin reduced hippocampal corticosteroid receptors and increased cort. response to stress. In particular, high responder rats did were not affected, but low responder rats, which had increased brain MR/GR and more efficient negative feedback, were affected (decreased cort. receptors and increased cort. response). In the other study, rats adrenalectomized and sub. with cort. who were treated with praz. chronically, showed a reduction in hippocampal MR levels, while adrenal-intact rats showed a reduction in hippocampal GR, and enhanced cort. responses following stress.
Another study was done where chronic treatment with prazosin to early abstinent alcoholics for 5 weeks seemed to reverse the blunted HPA response to stressors.
After 5 weeks with the alpha 1 antagonist, the praz. group was tested with stressors and showed a robust cort. response, in comparison to the placebo group which showed blunted response. It is said that HPA dysfunction in early abstience is marked by blunted HPA responses to stress and this increases relapse risk. The author of the study attributed the cort. response to higher NA levels as a response to blockade, but did not consider the possibility that maybe praz. was somehow affecting CRh or hippocampal corticosteroid receptors involved in the feedback system. The two groups showed identical cort levels prior to stress test, and only the praz. group produced healthy cort responses to the stressors.
----------------------
Many veterans with PTSD use this drug and find it to be helpful for aspects of their condition, mainly helping to sleep and have less nightmares.
What does chronic blockade of alpha-1 adrenergic receptors do to the HPA axis? Could it be helpful in the hypoactive HPA observed in many cases, such as CFS, PTSD where enhanced negative feedback is one of the key features.
I spoke with one of the researchers of the two studies done on the rats, and they said that this drug does show promise in HPA dysfunction, but there is no money for more studies, or studies on humans. this is an old drug, and its already being used in PTSD simply because NA drive is observed to be hyperactive in PTSD.
[DLMURL]http://pubget.com/paper/17552999/Individual_differences_in_the_effects_of_chronic_prazosin_hydrochloride_treatment_on_hippocampal_mineralocorticoid_and_glucocorticoid_receptors[/DLMURL]
Innordinate
VIP Member
hm.
Innordinate
VIP Member
That was an - I don't know what I'm talking about thing.
I've taken minipress though, and it worked but the dose was high enough I had symptoms of low blood pressure, dizziness and feinting. My Psychiatrist added another med and between the 3 medications I was taking at the time I had some not so nice complications and interactions. So I quit taking it. When I quit the minipress the nightmares came back worse than I've ever had them.
Not sure if it made my cravings for alcohol more or less or unchanged though. I was sober at the time.
I've taken minipress though, and it worked but the dose was high enough I had symptoms of low blood pressure, dizziness and feinting. My Psychiatrist added another med and between the 3 medications I was taking at the time I had some not so nice complications and interactions. So I quit taking it. When I quit the minipress the nightmares came back worse than I've ever had them.
Not sure if it made my cravings for alcohol more or less or unchanged though. I was sober at the time.
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