Do you find it more bothersome than other medications? From what I've read it seems getting the blood levels with lithium exactly right so that you need regular blood tests or something...? Are there any other restrictions?I've been on a dozen antidepressants over the last couple of decades. None seemed to work. In the last year I was diagnosed with bipolar I. I was put on Lithium 450 in the am and pm. Seems to work okay for me.