I started taking Sertraline (trade names Zoloft, Lustral) last summer. They had no positive psychological effect, so my dosage was gradually increased until I was on 200mg. However, they still had no benefit to me. Throughout my time on sertraline, I suffered with diarrhoea. Also, as my dosage increased, I experienced profuse sweating with just the slightest exersion. After about 1 month on 200mg, I was unable to cope with this side effect, due to the physical nature of my job.
However, I have been trying to come off sertraline now since the beginning of November, and I still have side effects. I have a pins and needles/ or zapping sensation throughout my body, if I drop too low, too quickly. The profuse sweating has now stopped and I currently take 50mg every other day, to stop the side effects. However when I try to reduce further, the 'zapping' begins again. I honestly thought that I would be okay coming off them, but the experience has been, and still is horrendous.
As has been stated already - everyone's experience with antidepressants is different, and no 2 people are the same. Even in this thread, experiences differ hugely, but I thought I'd share my experience. I hope you manage to benefit with little or no side effects.
Regards, CB.