Research Buprenorphine Opioids For Triad Of Pain, Ptsd, Suds

[anthony]

Not sure whether I could call this a successful study: "In a retrospective cohort study, investigators found that twice as many veterans treated with the partial nociceptin opioid receptor agonist experienced improvement in PTSD symptoms, beginning at 8 months and increasing over time. In contrast, those treated with opioids experienced a worsening of symptoms."

The results aren't anything spectacular, IMHO, and is just another drug treatment regime. The longevity of taking opioid anything has proven science behind it -- it will f*ck you up in the long term. This is after having taken an opioid form for 8 months. OMFG... seriously? You put veterans on an opioid for 8 months even for placebo purposes! :eek:

Results: Twice as many veterans in the buprenorphine group (23.7%) compared to those in the opioid therapy group (11.7%) experienced improvement in PTSD symptoms (P=.001). Compared to veterans in the opioid therapy group, veterans receiving buprenorphine showed significant improvement in PTSD symptoms after 8 months, with increasing improvement up to 24 months (incidence rate ratio=1.79; 95% CI,1.16–2.77; P=.009). There were no differences in the longitudinal course of pain ratings between groups.

http://www.medscape.com/viewarticle/860028

Studies need to start shifting away from pharmacological treatments IMHO for mental health. They're proven hit and miss, they come with side effects a majority of people never had prior to taking a drug, yet here we are, still trying out different saleable drug forms as some fix. I think the evidence is already quite clear... pharmaceuticals are not the solution to PTSD.

 

[Powder]

Nootropics and nutrition, plus stress management and symptom reduction seems like a better method, even though it takes more patient training.

I've found that taking a large glass of grapefruit juice with thiamine (green tea active ingredient in powder form) seems to aid mood and anxiety for me without side effects other than a nice boost to cancer prevention and weight loss.

Taking a multivitamin aids my energy the next day. Eating a healthy diet, getting enough calming walking in, and enough sleep on a regular schedule seems to keep me lower on symptoms.

Stress and fatigue will get me every time. I'll get flashbacks during the day now, and like it says here, I don't want to turn to a sedative pill to cope.

 

[Fembot]

Buprenorphine has demonstrated efficacy and improved therapeutic window in cancer, nonmalignant and neuropathic pain conditions- Given its superior safety and efficacy profile, buprenorphine can now be considered as a FIRST line therapy for the treatment of a wide range of chronic pain conditions." J. Pain Res. 2015Dec 4

safety of buprenorphine is much superior over the marketed opioids - i) ceiling etfect on respiratory depression; much lower risk vs other opioids; ii) lower constipation risk vs other opioids; iii) safest opioid for CNS immune-suppression issues; iv) anti-hyperalgesic profile and low tolerance issues; v) low clearance through renal path; no clinicaliy relevant changes in patients with renal impairment; vi) safer option for seniors; minimal drug-drug interactins and minimal influence on PK. Buprenorphine continues to be used as an effective treatment for opioid addiction duing induction, stabitization, and maintenance phases. The recognition that there is no "ceiling effect" on analgesia and that buprenorphine can be combined with marketed opioids without concerns about withdrawal or precipitation is beginning to help patients suffering from moderate to severe pain." J. Pain Res. 2015 Dec 4.

After that sighted study in the December 4, 2015 Journal of Pain Research, in late February 2016, the FDA finally approved Belbuca (a buprenorphine med) for pain management (v. indication for opioid dependence treatment as with all other preceding bup meds). Medicare won't yet pay for it, but some private insurance will. There is still subutex and suboxone which can be taken in substitute, but, again, many insurances wont pay for those UNLESS you are diagnosed as an addict v. someone seeking chronic pain relief that wishes to skirt the significant and horrible consequences of traditional opioids.

and again, there is the 700+ person co-morbid study (Vets with PTSD and physical pain/injury sufferers) with the VA, that showed chartable improvement in PTSD symptoms through the direct reduction in a co-morbid patient's physical pain using buprenorphine.