Gamereign555
Diamond Member
I was actually looking for a connection between carbon monoxide poisoning and Ptsd, I was curious because I worked with a lot of chemicals also at the time I had my first panic attack, sure I had plenty of loss, abuse/trauma while growing up, but I can't help but wonder when I found this article what exactly caused the unexplained panic attack followed by post traumatic stress while I was at work one day, eventually being diagnosed as Ptsd. I know why I have Ptsd, but I am not positively sure and I probably never will be of what caused me to suddenly have the worst panic attack to this day still I have ever had, things would never be the same after this.
Is anyone familiar with this? It blames high levels of nitric oxide and peroxynitrite buildup in the nervous system which causes tissue damage. The theory is that certain short term stressors cause the buildup of the naturally occurring nitric oxide, which develops into a cycle and leads to long term illness.
From the site: The Pall Protocol -Treating Chronic Fatigue Syndrome - Treating Fibromyalgia
-----------------------------------------------------------------------------------------------------------------------------------
Nitric oxide (NO) is all over your body and plays important roles such as transporting oxygen to your tissues and transmitting nerve impulses. Until the late 1990s, however, it was considered a toxin, and Pall considers it a toxin in his theory. Multiple studies show changes to the central nervous systems of people with FMS and ME/CFS, and Pall says those changes would require high levels of NO.
Pall says high NO levels in the central nervous system in turn lead to elevated levels of peroxynitrite, which causes tissue damage. How do you get too much NO in your body? Pall lays out 12 possible stressors, 8 that lead to a direct increase, 4 that lead to an indirect one. The direct stressors are:
The Vicious Cycle
Pall proposes that once a stressor causes a build up of NO, it puts in motion a vicious cycle that consists of several self-perpetuating loops. From there, it gets extremely technical and difficult to understand unless you’re really knowledgeable about biochemistry. If you are, Pall has a complete diagram on his website. For the rest of us, here's an example of how just one 5-step loop works:
Shared Symptoms
Pall says elements of the NO/ONOO- cycle can explain a host of symptoms shared by CFS, FMS, MCS and PTSD. (He offers them as plausible causes, not established ones.) These symptoms include:
To break the cycle, Pall says it needs to be "down regulated," which essentially means slowing it down by eliminating things that trigger it. For example, if stress makes you feel worse, it needs to be reduced or managed. Beyond that, he believes the complexity of the cycle requires multiple types of treatment.
Pall's paper on the NO/ONOO- cycle outlines a multitude of things -- many of them nutritional supplements -- that he predicts will down regulate the cycle. (Remember that this theory is unproven and these agents untested for treating this group of illnesses.) He also lists the treatment regimens used by five doctors who've found success treating one or more of these conditions and says the treatments all are likely to down regulate the cycle. As with all treatment options, you should talk to your doctor about what is right for you.
Pall's not the only one pointing to nitric oxide as a possible cause of these illnesses. Several researchers examining NO's role particularly in fibromyalgia are calling for studies into whether antioxidants are an effective treatment.
Is the Pall Protocol Right for You?
Only you can decide which treatment is right for you, and you should be sure to discuss your treatment options with your doctor. In addition to many aspects of this protocol requiring a doctor's participation, you also should be closely monitored to ensure the treatment does not have a detrimental effect on your health.
Sources:
Martin L. Pall, School of Molecular Biosciences, Washington State University. All rights reserved. "Novel Disease Paradigm Produces Explanations for a Whole Group of Illnesses."
2007 ME Research UK. "Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms."
Is anyone familiar with this? It blames high levels of nitric oxide and peroxynitrite buildup in the nervous system which causes tissue damage. The theory is that certain short term stressors cause the buildup of the naturally occurring nitric oxide, which develops into a cycle and leads to long term illness.
From the site: The Pall Protocol -Treating Chronic Fatigue Syndrome - Treating Fibromyalgia
-----------------------------------------------------------------------------------------------------------------------------------
Nitric oxide (NO) is all over your body and plays important roles such as transporting oxygen to your tissues and transmitting nerve impulses. Until the late 1990s, however, it was considered a toxin, and Pall considers it a toxin in his theory. Multiple studies show changes to the central nervous systems of people with FMS and ME/CFS, and Pall says those changes would require high levels of NO.
Pall says high NO levels in the central nervous system in turn lead to elevated levels of peroxynitrite, which causes tissue damage. How do you get too much NO in your body? Pall lays out 12 possible stressors, 8 that lead to a direct increase, 4 that lead to an indirect one. The direct stressors are:
- Viral infection: ME/CFS, FMS
- Bacterial infection: ME/CFS, FMS
- Physical trauma: ME/CFS, FMS, PTDS
- Carbon monoxide exposure: ME/CFS
- organophosphorus pesticide exposure: ME/CFS, MCS
- Toxoplasmosis infection: ME/CFS
- Volatile organic solvent exposure: MCS
- Autoimmune diseases: secondary FMS
- Severe psychological stress: FMS, PTSD
- Ciguatoxin exposure (from seafood): ME/CFS
- Organochlorine pesticides: MCS
- Pyrethroid pesticides: MCS
The Vicious Cycle
Pall proposes that once a stressor causes a build up of NO, it puts in motion a vicious cycle that consists of several self-perpetuating loops. From there, it gets extremely technical and difficult to understand unless you’re really knowledgeable about biochemistry. If you are, Pall has a complete diagram on his website. For the rest of us, here's an example of how just one 5-step loop works:
- High NO level increases peroxynitrite level
- Peroxynitrite increase causes oxidative stress (a build up of molecules that damage cells. Studies link oxidative stress to ME/CFS.)
- Oxidative stress stimulates NF-kB (which controls expression of genes involved in immunity and cellular function)
- NF-kB increases production of the enzyme iNOS (inducible nitric oxide synthase)
- iNOS increases NO level, and we're back to step one
Shared Symptoms
Pall says elements of the NO/ONOO- cycle can explain a host of symptoms shared by CFS, FMS, MCS and PTSD. (He offers them as plausible causes, not established ones.) These symptoms include:
- Learning and memory dysfunction
- Fatigue and sleep disturbance
- Chronic excessive pain
- Depression and anxiety/panic attack
- Immune dysfunction
- Irritable bowel syndrome
- Food allergies
- Orthostatic intolerance/hypotension (drop in blood pressure when standing that makes you dizzy)
To break the cycle, Pall says it needs to be "down regulated," which essentially means slowing it down by eliminating things that trigger it. For example, if stress makes you feel worse, it needs to be reduced or managed. Beyond that, he believes the complexity of the cycle requires multiple types of treatment.
Pall's paper on the NO/ONOO- cycle outlines a multitude of things -- many of them nutritional supplements -- that he predicts will down regulate the cycle. (Remember that this theory is unproven and these agents untested for treating this group of illnesses.) He also lists the treatment regimens used by five doctors who've found success treating one or more of these conditions and says the treatments all are likely to down regulate the cycle. As with all treatment options, you should talk to your doctor about what is right for you.
Pall's not the only one pointing to nitric oxide as a possible cause of these illnesses. Several researchers examining NO's role particularly in fibromyalgia are calling for studies into whether antioxidants are an effective treatment.
Is the Pall Protocol Right for You?
Only you can decide which treatment is right for you, and you should be sure to discuss your treatment options with your doctor. In addition to many aspects of this protocol requiring a doctor's participation, you also should be closely monitored to ensure the treatment does not have a detrimental effect on your health.
Sources:
Martin L. Pall, School of Molecular Biosciences, Washington State University. All rights reserved. "Novel Disease Paradigm Produces Explanations for a Whole Group of Illnesses."
2007 ME Research UK. "Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms."
