Thankfully, I don't have experience with long periods of isolation, knock wood. However, my DF will often sleep to get that "isolation" and he's slept for days on end. When he does this, I don't go too far, but I do my own thing in the house: watch my TV shows he doesn't like, take the dog on long walks, laundry and dishes (calming, repetitive actions), pray, a good glass of wine, etc. One thing I've learned through the last year with my fiancee is that you have to take care of yourself too. You don't have to skip every outing he doesn't feel up to, and you don't need to babysit him 24/7. And if you're a spiritual person at all, use those resources. They don't always "help" but they can sure feel like they do!