I understand Sandra. If you are on high-dose prednisone or a similar glucocorticoid the side-effects can be terrifically bothersome..
Ganaxolone is not that kind of a steroid however and has none of the peripheral side-effects of glucocorticoids - so I wouldn't want anyone else interested in the study to get side-tracked over the word "steroid".
Estrogen, progesterone, pregnenolone, testosterone, allopregnenolone, cardiotonic steriods that effect the heart, DHEA, thyroid stimulating hormone (TSH), ACTH - these are just a few of the steroids our bodies make and that we require. Allopregnenolone is a steroid neurotransmitter that works in the brain affecting GABA receptors and thus anxiety, epilepsy, sleep, and neurogenesis. Ganaxolone seems to work like allopregnenolone in that it inhibits seizures, produces relaxation of the brain and doesn't effect glucose metabolism like prednisone or muscle-building like testosterone.
