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And I do not think you know what TR means -- it means simply that the available drugs do not stabilize me. 100 mg zoloft was fine for awhile. Then it wasn't working at all. Then we switched to 200mg and it worked for awhile. My body responded to it, and began to beat the typical max dose of zoloft. So we added Deplin. I do not expect to be on meds my whole life as I am in therapy as well. I used to have episodes every 7- 20 days that lasted 7 - 14 days long, and now I have gone 70 days without an attack. She can call it FU PTSD for alI I care. What she does works for me