I'd be upset and it would probably lead to all kinds of negative self-talk and more depression. While I understand that generally that others have lives and we are really the only ones who can help ourselves, when in the midst of that intense depression and/or distorted thinking mode, those kinds of thoughts don't really come to me. All that comes to me are "why is nobody responding?" "Why doesn't anybody care about me?" And if you are someone who is not accustomed to contacting crisis lines, it may not even be something you think about doing. I, for example, usually contact my therapist. So when he doesn't respond and I know he's not on vacation - like the last two weeks - I get crazy.
Depression does all sorts of things to the way we think about things, and rational thinking usually goes right out the door.