what does 'depression' have to deal with feeling shame?
I had crafted a much more elegant explanation and my computer froze. These are not my conclusions but rather ones I have came across; I am neither a brain surgeon or a neuroscientist so here is my interpretation in a nutshell.
PTSD, depression, and shame are all associated with various components of the limbic system.
PTSD is often said to affect the Hippocampus, Amygdala, and Prefrontal Cortex.
Shame is controlled by a section of the brain called the ACC (Anterior Cingulate Cortex) which has two parts, one connected to the Prefrontal Cortex and one connected to the Amygdala. The ACC controls how the brains senses and processes stimuli which in turn cues the emotional response illicted (with help from the Amygdala - this also plays a role in motivation).
Depression is associated with neurotransmitters, but also with the Hypothalamus, Amygdala, and Hippocampus.
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The Hypothalamus controls body temp, hunger, thirst, fatigue, sleep, etc.
The ACC appears to play a role in a wide variety of functions, including cognitive function, such as decision making, empathy, and emotion.
The Amygdala performs a primary role in the processing and memory and also emotional reactions
The Hippocampus is a major component in how our memory functions.
"The Prefrontal Cortex is highly interconnected with much of the brain, including extensive connections with other cortical regions, as well as subcortical areas. The dorsal prefrontal cortex is especially interconnected with brain regions involved with attention, cognition and action, while the ventral prefrontal cortex interconnects with brain regions involved with emotion The Prefrontal Cortex also receives inputs from the brainstem arousal systems, and its function is particularly dependent on its neurochemical environment" (neruotransmitters which again play a large role in depression and stress)
http://webspace.ship.edu/cgboer/limbicsystem.html
http://www.allaboutdepression.com/cau_02.html
Link Removed
http://en.wikipedia.org/wiki/Anterior_cingulate_cortex
http://en.wikipedia.org/wiki/Prefrontal_cortex