Ok there is a lot to unpack here and I really want to get to everything... but i may have to circle back on the shame and other symptoms- but this other stuff supersedes symptoms anyway...
YES its great to ask questions... I love it! if I can use my research to help people that's the whole point.., I'm not looking for lab rats ... I want to actually make real change in the world
Are you saying that the methylation patterns triggered by traumatic events can actually flag cells for attack by our immune system? I'm envisioning trauma as triggering (de)methylation leading to up/down-regulating the transcription of certain genes, which then effect all kinds of trauma responses... So, for the cells to be attacked, could the changes in methylation patterns, e.g., upregulate genes whose proteins are on cell surfaces and present as antigens... or perhaps downregulate proteins that identify the cells as "self" (i.e., not foreign?)? Just trying to envision how this might work. Very interesting, at any rate.
YES basically that's exactly what I'm saying.. I am not a geneticist, I stumbled on this correlation in my neuroscience and psych research actually - but so far has been the one answer to the dangling questions about trauma...
If you are into some light reading of research papers in the bathtub - here is a pretty good one that dives deeper to explain how this works probably better than I can..
Exposure to chronic stress, either repeated severe acute or moderate sustained stress, is one of the strongest risk factors for the development of psychopathologies such as post-traumatic stress disorder and depression. Chronic stress is linked with ...
www.ncbi.nlm.nih.gov
my research is about how to functionally change epigenetics by way of psychology and neuroscience (so anyone can do it!)... I get flack by my collogues for not staying in my lane... but hey that's how history is made!!!
Also, how might all of this fit in with neuroplasticity? For instance, is there an epigenetic component to the development and strengthening of trauma-shaped neural pathways in a way that explains the psychological fallout from trauma?
Yes, its not super straightforward to explain without a lot of jargon but I will try.. ( I try really hard to keep things easy for people to understand on here) ... but you are totally on the right track with what you are thinking... So, we actually can inherit trauma from previous generations... ( yup you got it from your momma- or her mom... or even her mom.. and maybe even hers...) research suggests that this can go back like 4-5 generations... it's pretty crazy when you think about it... it has some crazy implications about social issues like generational poverty and racism, and psychological issues/ disorders like anxiety, depression, schizophrenia and what we all think are medical conditions like heart disease, Alzheimer's and autoimmune issues... and many many more things...
Basically we are top down/ bottom up beings- we are part nature and part nurture... right? - Let's say you never met you uncle Joe (He died before your were born)- but your mom says you have his same eyes... ok we believe that is genetics, and his same laugh, ok maybe also genetics, but what if you stick your tongue out the same exact way that he did when you tie your shoes... This is the neural pathway that is associated with epigenetics ... a specific behavior that could in no way be taught to us... but some how we inherited this behavior... So yes we are neuralgically programmed to have certain behaviors.. the psychological fall out you speak of is our conscious minds and unconscious ( our body) trying to make sense of what is happening on the cellular level... the information systems go both ways... it gets information from chemical experiences in the body... and tells the cells how to react... Ill come back to this below...
Also - Here is another real life example of how this really infiltrate's our lives... the Jim Twins...
Upon hearing about the brothers' uncanny resemblances, researchers invited the ‘Jim Twins’ to come to their facility for testing.
allthatsinteresting.com
What about production of neurotransmitters/receptors? Is it possible that all our trauma symptoms, both somatic and psychologial, are ultimately mediated via epigenetics?
YES but
translated might be a better word?? (Technically-maybe not
all - research is still going here) -But Basically This is exactly what I am saying.... Epigenetics IS the link between our DNA, and our thoughts, Feelings and actions... (this is a deep subject- i dont know if i can really fully explain this here...)
Ok so Epigenetics is literally a translator... we are born with it-it comes with our DNA- so part of it is NATURE,
however our lived experiences can modify and trigger changes the Epigenetic blanket over our DNA to change its translation and signal on a different DNA Markers - NURTURE
In other words it is plastic and can be modified from top down or bottom up... ( I think this is where you are going with this?)
Again trying to make this simple for everyone...
Neural pathways change constantly as we experience
new things... but some neural pathways are like a deep rut... like water eroding the ground, the longer the water runs over the same spot, the deeper the rut... these are our repeated experiences- whether they are real or perceived ... ( like trauma memories) the mind doesn't know the difference between real or imagined, the original event, just a memory of the event, or a chemical surge similar to the event... it's why we can have visceral responses to thinking about a lemon for example...
The epigenetic response is the translation of experiences to trigger gene expression...the more often it gets the signal - ie from deep ruts- it is going to respond to say - "hey we need to change something in our DNA expression to stop this, because the rest of the systems in the body aren't doing it"... its the start button for evolution.... but it shows up as the body attacking itself... ( sort of a survival of the fittest - (which is actually not what Darwin said - he actually said something along the lines of "survival of the adapt-ist" - sorry tangent and almost irrelevant)
We get our DNA from our parents-- a combination of your mother and your fathers genome... but we also get our epigenetic translator too... so any of their experiences that were strong enough to turn on a genetic expression, we got that too... its a survival mechanism... then add in the nurture portion, ie the learned behaviors that your parents have based on their trauma... and double whammy... we inherit certain epigenetic translations that tell our brains to express certain chemicals based on certain situations... And then we create our own.
I know this is where i lose my fellow scientists... because people think its whoowhoo and not real science, maybe because they have seen too many Vegas hypnosis shows?? or it seems too simple? I don't know... I do not consider myself a spiritual person, I really am a curious scientist....
( Please note that many therapists and other professional often interchange unconscious and subconscious- i know and understand the Unconscious to be part of the active experience and is the Body - the subconscious to the neutral - un -feeling entity records all information without emotion.)
So if I haven't lost you yet let me try to explain it this way...
Our thoughts - the internal dialog that we speak- is actually understood by the
Subconscious mind before we are even born and it starts recording everything...
when we are born ( or around then) our
Conscious mind switches on, we begin to enhance this vocabulary with our experiences...
The thoughts we continue to think become beliefs... Sun= warm, snow = cold, we 'know' these things... and therefor this information is recorded by our subconscious mind and translated it to our UNconscious mind - which IS the BODY... This is where we experience emotions, feeling and creates behavior...
Memories of these experiences are just a cluster or collage of experiences with similar conditions that tell us what to do with the information. This is where the neural pathway is formed... the stronger the neural pathway the deeper the "rut" - so it becomes the path of least resistance... the more often we fire this neural pathway our epigenetic signals tell our DNA what to turn on and off... which type of cell to become etc.... Epigenetics keep score...
a Trauma memory is a collage of memories that is missing some information from the conscious and unconscious experience... basically you experienced new or heighten emotions or thoughts that were unlike anything you had experienced before, so there are holes in the collage... these trauma memories wait in the body for the rest of information to come along an fill in the banks so it can form a helpful neural pathway-so it can help inform you in the future as to what actions to respond with...
the rest of this information often doesn't come along for a while... so this incomplete collage sits, festering- it's literally chemicals like cortisol and adrenaline that hang out on the cells of your body... your epigenetics, sits on top of your DNA - which is inside the nucleus of the cells. It's watching from inside the bubble, and when the cortisol/ adrenaline black cloud covers the cell... your epigenetic observers watch, if it stays for too long, it starts switching on and off DNA markers - arming the cell to fight this enemy... cells fight from the inside and the brain feels the fight and cuts off that part of the body to protect itself.
Super good news - Epigenetic changes are totally reversible... it's malleable. there is no surgery or special medicine that can just target the trauma markers (yet) ... but if we can rise above our symptoms...( and I know this seems really hard for people who are crippled by the psychological and somatic responses.) and be deliberate with specific thoughts, and actions, we can re-wire new neural pathways, based on perceived experiences.... then once we have control of the language of the subconscious, we can then fill in the gaps of the memory collage... and release the black cloud over the cells... and then we can over-write the misfired epigenetic signals... This is some serious mind over matter kind of stuff...and where for me- hypnosis comes in.
My cousin is an illusionist by trade... and I knew some of her magic friends, so I was already open to and intrigued by hypnosis... and at first I thought it would just help me dissociate and numb what I was feeling- or that I could make the nightmares and flashbacks stop... but it was so much more than that...
I am now certified in hypnotherapy - ( I cannot treat you via this forum, and I don't feel comfortable sharing inductions in the public side of the forum because of the nature of the space... however I can totally get you pointed in the right direction after I get a little more info from you if you don't mind chatting via private massage :) )
I also worked with somatic body workers...
Trauma informed massage therapist and physical therapists, who I spent nearly a year with, learning to walk again and correct neurological damage... Working with these body workers, sometimes I would cry out of the blue with just a simple touch on the small of my back.... I wouldn't be feeling overwhelming emotions, but I would have the physical symptoms of the emotions...it was a bit out of body ... I learned how to literally turn this on and off, then I learned how to turn on and off my pain ... my doctors would constantly tell me I shouldn't be able to do that... eventually they helped me release the trauma from my body..
Also, I worked with a therapist on some EMDR-- which I also recommend to help curb the symptoms -and allow you to get into a trance state more deeply so you can work on the neural pathways without the annoying distraction of anxiety and pain...
( you can read my welcome story for the details of what I went through- but basically I struggled with Complex Post Traumatic stress for 30+ years from childhood sexual abuse, and then my learned behaviors and epigenetic triggers actually programmed me to walk right into a totally unrelated s#!T storm... I was kidnapped, repeatedly beaten and raped and ultimately survived attempted murder....) I knew that it was not a coincidence that I kept experiencing traumatic events... I wasn't just unlucky.... or doomed... In my teen and early 20's I actually witnessed several accidents and even pulled a person out of a burning car- it was like I was still programmed to find trauma... but for a while I was on the other side of it where I was actually helping people...this period of time is when I was also experiencing the fewest or almost NONE of my PTS symptoms... ) I knew that there was something to it... and people tell my things like " it's gods plan for you" wasn't sitting well... so I put my hypervigilance to work and decided to go for my masters to understand what I had done for myself and how I can help others do this... I opened up a can of worms for sure... but it's all good stuff... that I know will someday help others who are struggling!
If any of this resonates with you- I hope it helps... I am sure that dealing with the autoimmune issues on top of the psychological symptoms feels like a lot to handle.... but I encourage you to keep chasing your curiosity... please let me know if you have any other questions ...
I'd say my somatic symptoms are less troubling than my psychological ones are, most of the time (i.e., when I'm not having a somatic flare-up). But yeah, dissociation has been very problematic, along with depression/shame/toxic ruminations, and insomnia. They all seem to be related: dissociation causes various types of dysfunction, which feeds into various types of shame, which feeds the involuntary depressive ruminations about how much of a reject/loser I am, and my brain is generally buzzing with this type of junk (or panicking about some assumed future catastrophe), which (in addition to my general somatic hyperarousal) leads to the insomnia
Ok and lastly - I actually want to chat with you more about this... may I message you directly and ask for some more specific details about what these experiences look like. ?
Thanks again for your help!