Yes, I took risperidol to replace zyprexa that put 50 gd pounds on me. But I didn't get the mental help and I swelled up all over my body. Now I take Geodon . It's good for my depression and compulsive tendencies and I've been able to lose some weight. I had night sweats with it too. Have to have occasional EKGs on Geodon it can affect the heart rhythm.[DOUBLEPOST=1406494359,1406494147][/DOUBLEPOST]Oh and I was done menopause when I took it, so can't comment on that. All brain meds affect the endocrine system. Many cause unwanted hair growth or changes with stress and sex hormones. It's a benefit/risk decision.