Antidepressants make me high. Ever since I started on my very first antidepressant, Prozac, at the age of 16, and doctors failed to realize that I was going manic. It happened two more times. Once again on Remeron, and then again on Remeron. Yes, I was stupid enough to try that one twice. I don't trust psychiatrists because they all know my history with getting "high" on antidepressants yet because of my depressive symptoms, insist that I go on an antidepressant yet again. I simply refuse. I have a mood cycling problem, not so much a major depressive problem. I am now on two mood stabilizers, and am doing much better. I know that antidepressants can help many, but trust your own instincts. Psychiatry is much a guessing game, and you are the guinea pig. Doctors never know how you are going to react to a medication. Hugs.