I have been on Cymbalta for 7 years, I started on 30mg went to 90mg used to help my Depression and Chronic Back Pain.
Bad side: every time I have a dose change (up or down) I go a little "crazy" for about a week. *Bursts of anger, tears, yelling, throwing cups/pens at walls. After I learned this I just plan a low stress, no appointment week if dose changes are needed.
I was taken off Cymbalta July 2011 by a new pain specialist, I had been on it 90mg for years My pain was off the charts so I figured it had stopped working. I was put on Lyrica instead. Lyrica should come with a huge warning if not pulled (for pain management) completely. I had a small Stroke after 2 1/2 weeks before reaching recommended dose. After recovering I researched this, Stroke IS a listed Side Effect of Lyrica. How can they give this to people? Sorry back to Cymbalta...
The Good: After my time off of Cymbalta in mid 2011 I realized how much good it was doing. so I started it again at 30mg, 1week later I braced for the mood swings and went to 60mg where I stopped this time, much less emotional YoYo this time. So even with these side effects Cymbalta is Absolutely worth it for ME.
Side Note: I have been on the Medication "Wheel of Torture" aka "Pill Guinea Pig" ie. trying to find the right medications, as few as possible while still being able to function, with the least side effects and interactions for over 17 years.
I have talked to my Primary Dr. & Psychiatrist, followed by online research - The emotional rollercoaster I go through with dose changes is considered rare however it is more common in people of Polish, Russian, Icelandic, and Scandinavian decent.