PTSD only, no other diagnosis. I voted no medication. I had a very negative response to Cymbalta, and now anti-depressants and such are prescribed very sparingly for me.
Pros? I don't have to deal with the stigma or looks at the pharmacy when picking up medication. I don't have to deal with the looks of pity from office staff in the doctors office, and I don't have the negative reactions I once experienced; mostly extreme anxiety. Benzodiazepines tend to blunt my emotions, which is great for anxiety, but make it so although I know something is wrong, I can't tell what. Self-help is difficult during times of apathy and lack of motivation, but they are integral and vitally important when medication is not being used (in my humble opinion). I would rate my level of functioning at moderately impacted. I am also coming out of an apathy or numbing period, so feeling emotions are a bit overwhelming to me right now, but I imagine that will pass as I attack and address the "next layer" to go through. It is physically exhausting, and I have no desire to leave the house.
What works best to treat my symptoms in the absence of pharmacology are all the coping mechanisms recommended. Exercise, ensuring I eat enough calories in that day (I lose my appetite very easily), ensuring I eat enough protein (instantly improves my mood if it's due to not eating), yoga, breathing exercises, and just generally forcing myself to live a normal life even when I don't feel like leaving the room. Again, my level of functioning would be improved if I were more successful in kicking my own butt in motion.
I have found short-term benzodiazepines to be very effective for PTSD symptoms that involve gastrointestinal upset, and other physical symptoms, along with sleeplessness. Cons for this method include blunting of emotions even more, along with increased anxiety over not being able to discern what the problem is when you do feel something. I have a fear of doctors after my experience with Cymbalta, and have significant difficulty in trusting them and their prescriptive behavior afterward.