I need everyone to know about this drug. It's called Auvelity.

[Flossy]

AM only - even low levels of DXM will make it difficult for you to sleep if you take it before bed. You should aim to take your last dose, if you break it up into 2 as done with Auvelity, at least 6 hours before going to sleep. I take 120mg once per day in the morning, and I weigh ~110-115 lbs (my weight tends to fluctuate, but usually no higher or lower than that).

Do you take an anti-depressant of any kind? Do you find there is any interaction with the DXM.?

 

[Weemie]

Do you take an anti-depressant of any kind? Do you find there is any interaction with the DXM.?

I do not. Auvelity is a combination of DXM and buproprion - which inhibits conversion to DXO (some of the DXM you ingest normally gets converted into DXO, which is what most benefits me. Thus I elect not to use buproprion concurrently), but potentiates DXM.

So at least one antidepressant is able to be safely mixed with the drug, but you would need to research the dosage amounts. In Auvelity it is 105mg of buproprion and 45mg of DXM per tablet. However, DXM can contribute to serotonin syndrome which means it can interact with certain antidepressants like SSRIs. Buproprion, being an NDRI, has less action on serotonin receptors than a medication like Zoloft, for instance.

What antidepressant are you on and how many milligrams per day do you take of it? I could give you a better answer with specifics.

 

[Flossy]

I do not. Auvelity is a combination of DXM and buproprion - which inhibits conversion to DXO (some of the DXM you ingest normally gets converted into DXO, which is what most benefits me. Thus I elect not to use buproprion concurrently), but potentiates DXM.

So at least one antidepressant is able to be safely mixed with the drug, but you would need to research the dosage amounts. In Auvelity it is 105mg of buproprion and 45mg of DXM per tablet. However, DXM can contribute to serotonin syndrome which means it can interact with certain antidepressants like SSRIs. Buproprion, being an NDRI, has less action on serotonin receptors than a medication like Zoloft, for instance.

What antidepressant are you on and how many milligrams per day do you take of it? I could give you a better answer with specifics.

I take 200mg of Pristiq (Desvenlafaxine) which is an SNRI. Not SSRI. 200mg is a high dose. I have tried to titrate down to 100mg but become teary on that dose with nothing else. A thought has been that one DXM or one and a half plus 100mg Pristiq could be a trial

I took a 30mg DXM yesterday and I felt heightened alertness and ability to function which felt quite pleasant and comfortable. There was a slight feeling of irritability after it wore off in about six hours.

I do not know what DXO is. I will look into that. Any input is valued, thank you. The DSM does wonders for my husbands ability to focus.

I was on Bupropion alone for some months, but found the cost in Australia prohibitive as it is not government funded for depression. Alone it was not enough for me but when I read back my posts on it I was coping a lot better.

 

[Weemie]

I take 200mg of Pristiq (Desvenlafaxine)

Just be aware that desvenlafaxine has activity on CPY2D6, which can result in your serum levels of DXM being much greater than the dose that you actually take. This can increase the possibility of serotonin syndrome (which SNRIs including this one, can cause), so just be aware that given your high dose of this drug and its ability to potentiate DXM, you are at a slightly elevated risk of developing serotonin syndrome.

Take it very low and slow. 30mg of DXM is unlikely to result in this, but you are on a pretty high dose of a medication that can prevent the DXM from breaking down in your body. This means that say, for example, you took another 30mg today - the 30mg from yesterday could still be there, resulting in having 60mg at once. That's not exactly how it works, but if you notice any discomfort, stop taking the DXM immediately or wait longer periods between dosing.

 

[Sideways]

Nb - the high end dose of desvenlafaxine is around 400mg a day. So you’re pretty safe at 200mg (I take it myself - I sat on 250mg a day for several years).

 

[Flossy]

Just be aware that desvenlafaxine has activity on CPY2D6, which can result in your serum levels of DXM being much greater than the dose that you actually take. This can increase the possibility of serotonin syndrome (which SNRIs including this one, can cause), so just be aware that given your high dose of this drug and its ability to potentiate DXM, you are at a slightly elevated risk of developing serotonin syndrome.

Take it very low and slow. 30mg of DXM is unlikely to result in this, but you are on a pretty high dose of a medication that can prevent the DXM from breaking down in your body. This means that say, for example, you took another 30mg today - the 30mg from yesterday could still be there, resulting in having 60mg at once. That's not exactly how it works, but if you notice any discomfort, stop taking the DXM immediately or wait longer periods between dosing.

I will keep this in mind at all times. I am unsure if I will/would take DXM on a daily basis at this point as I feel well enough most days unless there is a stress coming in to my life that drags me down the sh#t Shute. I will be trialling different ways to see if it helps me.

I guess the goal would be to also reduce the Pristiq down to 100mg. I like to make sure that any changes I make are one at a time so that I can be sure that my responses are caused by only one factor. Thank you for your input, I appreciate it very much.

 

[Flossy]

Nb - the high end dose of desvenlafaxine is around 400mg a day. So you’re pretty safe at 200mg (I take it myself - I sat on 250mg a day for several years).

Did you reduce from that dose as life stressors reduced?
I take it for its' effect on panic attacks ( have not had one for fifteen years) and also it works for my Fibro pain. Would you share what you feel it has done for you please? Just for interests sake.

 

[Sideways]

Would you share what you feel it has done for you please? Just for interests sake.

It helps me manage my depression. I was able to bump my dose up and down depending on how I was doing, but I’m now slowing weaning off it because my symptoms have been fairly manageable for a while.

 

[brokenpony]

my psychiatrist mentioned this drug to me but my insurance won't cover it. at least not without a fight. i am intrigued now though.

 

[Flossy]

my psychiatrist mentioned this drug to me but my insurance won't cover it. at least not without a fight. i am intrigued now though.

The DXC or the Pristiq?

 

[brokenpony]

The DXC or the Pristiq?

auvelity

 

[Flossy]

auvelity

auvelity

Well, if you are wanting to trial it, it is available though the link that Weemie put up in a low dose and not expensive at all. The DXM part of it is anyway. I am trialling it with my Pristiq as in Australia Wellbutrin isn't available. Basically, Auvelity is Wellbutrin and DXM. If your insurance will cover Wellbutrin you can access the DXM through Amazon or the website Weemie put up early in her post. I have found it is good for when motivation is lacking.