I have to isolate multiple times during the day. I can barely stand it and will absolutely have effects if I don't. I am 'exquisitely triggered' per my therapist by my H (he is borderline personality/narcissist and I actually became disabled somatizing my Anxiety into pain for the last 20+ years w/PTSD, and a bunch of other stuff) so I have to get away from him. I am trying to work up the guts to tell him I need him to move into the other bedroom 'for awhile' to get away from him and the pressure/hypervigilence I feel around him. Sleep sucks and I am on a journey trying to fix all this crap as much as I can but it is hard to put yourself first for the first times of your life. Isolation to me is like taking your shoes off at the end of a hot day - ahhhhhhhhhhhhhh. If someone felt the need for isolation, I would hope those around them would cooperate and help the person. It's not like we want this. (Asking this about the bedrooms would be a terrible request except for a long history I won't go into. I actually have every right in the world to ask.)
Isolation must mean and be many things to different people then - a way to alleviate what we live with, peace, escape, healing, or like some members here...a bad sign for them. Isolation is the only time I am at peace (ish :).