Based upon my own subjective experience, I would say yes - yes in a big way.
The past few years have been very, very stressful (job loss, custody issues, financial issues - I could go on). Between Christmas 2015 and New Year's 2016, sometime during that week, an old neck injury compounded by time and arthritis returned resulting in the most excruciating pain I have ever, ever felt.
I left work for the local ER, I believe, the second week of January 2016 and was given one of the Predisone bubble packs (which I later learned aren't deemed to contain in effective dose). It provided some small relief, but, long story short, I went onto have three more (and more powerful) cycles through June 2016. (I should note that I changed jobs without a break in late January.)
The second and third doses were very effective in managing pain (I couldn't take time off being the newbie).
I have taken Prasozin for PTSD nightmares for several years, and I've had moments, 25+ years on, zoning out/dissociating. As late as June 2016, my neck was still killing me, but to speak to the point, it was like a virtual time warp -- to the point at which "everyone else is crazy." Literally, I would walk past colleagues in the hall, not seeing them ... as of today, I'm into month 5 of short-term disability from work, and am to be evaluated for long-term disability by the insurer very soon. I'm still breaking down, as recently as yesterday afternoon in my doctor's office, mere mention of events. Like the protective armor wore off.
Okay, so, not intending to rail against a medication that has some great benefits, albeit as I've heard it been described as "the best worst drug" and "the drug of last resort." And, obviously, my experiences are at root of it, and there was a span of several months before things really blew up, but the spike in anxiety ... my PRN over the summer quadrupled, in effect, to a chronic administration of Clonazapam amounting to 4 mgs a day.
Who clued me into what, I feel, I should have surmised was an ER nurse as I was awaiting a psych eval and the results of a toxicology screening prior to admittance to a psychiatric ward in December 2016. Previously, I hadn't considered the psychopharmacological effects of the medication, but intuitively the association of a stress-hormone precursor to someone with a trauma history might pose some risks.
Last note, the nurse who informed me spoke directly to its association with provoking manic responses in certain patients.
