Well, recently, I had an opportunity to try Sativa bucal spray (mouth spray), manufactured by Bayer; it's dispersed in my country only for things like cancer, and it's hard to get a prescription for it as only few doctors prescribe it. But out of empathy, re: disabling chronic pain/fatigue/arthritis, a friend witnessing me struggle through work, let me try his spray later that night-- it was awesome! (Friend has Combat-PTSD; cancer from DU exposure (dupleted uranium); other injuries from service to joints, etc. War has it's costs, that's for sure. He's inspiring; he pulls off day-to-day with enormous courage and grace; paces himself; does great work; definitely a hero figure to me).
Pain was keeping me up at night, and having pain all day, but with extreme fatigue-- this stuff let me sleep so pleasantly-- a good body-buzz, like laying in a hot bath, soothed, no pain, and also no anxiety or weirdness happening to the mind-- mind felt clear. And it seemed to have a longer lasting effect, so that pain/fatigue didn't bother me for the whole week (even though it was raining and that's been bad for me). Mentally, I was doing great as well (and I was dealing with stuff, I'd expect would trigger me, though I have better coping now, able to manage flashbacks better, at least some of the main ones).
There is something to its properties for reducing inflammation and also for relaxing muscles which can tense up in response to pain (and also in response to PTSD symptoms, over time, the body can get really cramped up too, carrying stress, constriction, wear from fight/flight-- I also got TMJ, etc. gritting my teeth, grinding, etc-- chronic stress over many years, anger too). For pain management, I imagine if pot can replace or limit use of opiods (which are much more addictive, tolerance-building), that can't be a bad thing. If it can help limit the physiological damages from chronic-PTSD, that too is interesting. . .